Group/Corporate Codes
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Special Offers

Located in the heart of the Texas Medical Center, our full-service hotel accommodating both short and long-term stays with stylish rooms, modern décor, and thoughtful lifestyle amenities, such as free Wi-Fi, shuttle service and affordable self-parking and valet parking. Guests will enjoy our seasonal outdoor pool and fitness center. We offer convenient business amenities, like print, copy, and fax services and meeting space for up to 10 people. Room service is available daily, or dine in at our onsite restaurant, Main Street Bar and Grill, for breakfast, lunch and dinner.

Houston Hotel Deals That Are Out of This World

From weekend getaways to dining specials, we've got you covered with exciting hotel packages that help you experience Houston in luxury. Enjoy delicious food, drinks, parking and beautiful accommodations that put you in the heart of Houston's vibrant medical and museum district.

Save the Children

You Stay, We Give. We Donate $5 For Every Qualifying* Night.

Shopping Package

Shop Til You Drop with rates starting from $129! Rejuvenate your mind, body, and wardrobe. Book the Wyndham Houston Medical Center Shopping package for Friday and/or Saturday night, discover a new look and get your retail therapy today.

Exclusive AAA Package: 10% Off + Breakfast

Make your reservation anytime between now and August 31, 2017 for stays through the end of the year and enjoy breakfast for two plus a nice discount.

Book Direct for Our Best Rates & Points!

Book directly on our website to receive our guaranteed best rates! Plus, if you are a Wyndham Rewards member, you’ll also earn Wyndham Rewards points that you can redeem for future vacations.

Museum of Natural Science Package

The Houston Museum of Natural Science is one of the most popular and attended museums in the country, with its large number of permanent and guest exhibits, including the Burke Baker Planetarium, Cockrell Butterfly Center, Wortham Giant Screen Theatre, Morian Hall of Paleontology, and many more. Our Museum of Natural Science Package includes two general admission tickets and complimentary breakfast buffet for two.